Platinum complexes, such as cisplatin, carboplatin, and oxaliplatin, have been used since the early 1970s to treat various solid tumors (testicles, ovaries, head, neck and, recently, colon). It was found that platinum is fixed in a covalent way to the DNA, forming various types of adducts. The tumor treatment properties of platinum complexes are directly connected to the fixation of platinum on DNA.
The influence of platinum on the reparation of DNA is dependent on the time the injection was done in an organism. This is the same for the toxicity that platinum complexes can reveal on other organs, which is determined by analyzing solutions coming from extraction of target organs over time. The quantity of solutions is around 1
milliliter.
Phosphorus and sulfur were also determined.Phosphorus allows direct determination of the proportion of platinum to nucleotide, knowing
that there is one atom of phosphorus per nucleotide of DNA. ICP電感耦合全譜等離子體發射光譜儀 ICP電感耦合等離子體發射光譜儀-高性能低成本GX率的操作平臺 ACTIVA-M 新型等離子體發射光譜儀 ACTIVA-S 新型等離子體發射光譜儀
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